|
Chemistry
ONCONASE® (ranpirnase) is a single
peptide chain containing 104 amino acids. Ranpirnase has a molecular mass
of approximately 12,000 daltons and an isoelectric point of approximately
9.5. The amino terminal residue is pyroglutamate.
Mechanism Of Action
In cancer cells, ONCONASE-induced intracellular RNA
degradation triggers several biological effects simultaneously including
the induction of the "intrinsic" (mitochondria) pathway of apoptosis and
modulation of the expression of several key cell cycle regulatory factors
|
|
|
